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apol1 database  (Human Protein Atlas)

 
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    Human Protein Atlas apol1 database
    <t>APOL1</t> is highly expressed in clear cell renal cell carcinoma. (A–C) Heat map of hierarchical clustering (A) , multidimensional scaling (B) and APOL1 mRNA expression (C) in RNA-seq of 9 patient ccRCC tumors compared to their adjacent normal tissues. (D) Kaplan-Meier survival analysis based on the APOL1 expression at stage 4 and grade 4 in the TCGA-KIRC dataset. (E, F) qRT-PCR analysis of APOL1 mRNA (E) and western blot analysis of <t>APOL1</t> <t>protein</t> (F) in A-498, 786-O (primary cancer) and Caki-1 (metastatic) cells compared to HK-2 (normal) cells. Actin served as an internal control.
    Apol1 Database, supplied by Human Protein Atlas, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/apol1 database/product/Human Protein Atlas
    Average 90 stars, based on 1 article reviews
    apol1 database - by Bioz Stars, 2026-03
    90/100 stars

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    1) Product Images from "Apolipoprotein L1 is a tumor suppressor in clear cell renal cell carcinoma metastasis"

    Article Title: Apolipoprotein L1 is a tumor suppressor in clear cell renal cell carcinoma metastasis

    Journal: Frontiers in Oncology

    doi: 10.3389/fonc.2024.1371934

    APOL1 is highly expressed in clear cell renal cell carcinoma. (A–C) Heat map of hierarchical clustering (A) , multidimensional scaling (B) and APOL1 mRNA expression (C) in RNA-seq of 9 patient ccRCC tumors compared to their adjacent normal tissues. (D) Kaplan-Meier survival analysis based on the APOL1 expression at stage 4 and grade 4 in the TCGA-KIRC dataset. (E, F) qRT-PCR analysis of APOL1 mRNA (E) and western blot analysis of APOL1 protein (F) in A-498, 786-O (primary cancer) and Caki-1 (metastatic) cells compared to HK-2 (normal) cells. Actin served as an internal control.
    Figure Legend Snippet: APOL1 is highly expressed in clear cell renal cell carcinoma. (A–C) Heat map of hierarchical clustering (A) , multidimensional scaling (B) and APOL1 mRNA expression (C) in RNA-seq of 9 patient ccRCC tumors compared to their adjacent normal tissues. (D) Kaplan-Meier survival analysis based on the APOL1 expression at stage 4 and grade 4 in the TCGA-KIRC dataset. (E, F) qRT-PCR analysis of APOL1 mRNA (E) and western blot analysis of APOL1 protein (F) in A-498, 786-O (primary cancer) and Caki-1 (metastatic) cells compared to HK-2 (normal) cells. Actin served as an internal control.

    Techniques Used: Expressing, RNA Sequencing, Quantitative RT-PCR, Western Blot, Control

    miR-30a-3p suppresses APOL1 expression. (A–C) Heat map of hierarchical clustering (A) , multidimensional scaling (B) and miR-30a-3p expression (C) in miRNA-seq of 9 patient ccRCC tumors compared to their adjacent normal tissues. (D) Pearson correlation analysis between miR-30a-3p and APOL1 in patient ccRCC tumors. (E) Kaplan-Meier survival analysis based on the miR-30a expression in the TCGA-KIRC dataset. (F) Western blot analysis of APOL1 protein in control and miR-30a transfected A-498 and 786-O cells. Actin served as an internal control.
    Figure Legend Snippet: miR-30a-3p suppresses APOL1 expression. (A–C) Heat map of hierarchical clustering (A) , multidimensional scaling (B) and miR-30a-3p expression (C) in miRNA-seq of 9 patient ccRCC tumors compared to their adjacent normal tissues. (D) Pearson correlation analysis between miR-30a-3p and APOL1 in patient ccRCC tumors. (E) Kaplan-Meier survival analysis based on the miR-30a expression in the TCGA-KIRC dataset. (F) Western blot analysis of APOL1 protein in control and miR-30a transfected A-498 and 786-O cells. Actin served as an internal control.

    Techniques Used: Expressing, Western Blot, Control, Transfection

    APOL1 overexpression in renal cell carcinoma reduces the metastasis in vitro and in vivo . (A–C) Western blot analysis of APOL1 protein in control and APOL1 knockdown A-498 cells (A) , APOL1 knockdown 786-O cells (B) and APOL1 overexpressing Caki-1 cells (C) . Actin served as an internal control. (D, F, H) Wound healing analysis of control and APOL1 knockdown A-498 cells (D) , APOL1 knockdown 786-O cells (F) and APOL1 overexpressing Caki-1 cells (H) . Scale bar, 100 µM. (E, G, I) Transwell migration and invasion analysis of control and APOL1 knockdown A-498 cells (E) , APOL1 knockdown 786-O cells (G) and APOL1 overexpressing Caki-1 cells (I) cells. Scale bar, 100 µM. (J, K, L) Number of lung metastatic nodules (J) , representative image of the dissected lung (K) and H&E staining of lung (L) in mice intravenously injected with control and APOL1 overexpressing Caki-1 cells. Scale bar, 100 µM.
    Figure Legend Snippet: APOL1 overexpression in renal cell carcinoma reduces the metastasis in vitro and in vivo . (A–C) Western blot analysis of APOL1 protein in control and APOL1 knockdown A-498 cells (A) , APOL1 knockdown 786-O cells (B) and APOL1 overexpressing Caki-1 cells (C) . Actin served as an internal control. (D, F, H) Wound healing analysis of control and APOL1 knockdown A-498 cells (D) , APOL1 knockdown 786-O cells (F) and APOL1 overexpressing Caki-1 cells (H) . Scale bar, 100 µM. (E, G, I) Transwell migration and invasion analysis of control and APOL1 knockdown A-498 cells (E) , APOL1 knockdown 786-O cells (G) and APOL1 overexpressing Caki-1 cells (I) cells. Scale bar, 100 µM. (J, K, L) Number of lung metastatic nodules (J) , representative image of the dissected lung (K) and H&E staining of lung (L) in mice intravenously injected with control and APOL1 overexpressing Caki-1 cells. Scale bar, 100 µM.

    Techniques Used: Over Expression, In Vitro, In Vivo, Western Blot, Control, Knockdown, Migration, Staining, Injection

    APOL1 suppression activates Akt signaling pathway in clear cell renal cell carcinoma. (A) GSEA of RNA-seq data from patient ccRCC tumors compared to their adjacent normal tissues. (B) Gene enrichment analysis of 212 upregulated genes in patient ccRCC tumors. (C, D) Western blot analysis of Akt, NFĸB, GSK3β protein in control and APOL1 knockdown/overexpressing renal cells (C) , and miR-30a transfected A-498 and 786-O cells (D) . (E) Western blot analysis of focal adhesion proteins in control and APOL1 knockdown A-498 cells, APOL1 knockdown 786-O cells and APOL1 overexpressing Caki-1 cells. (F) Western blot analysis of EMT markers in control and APOL1 knockdown A-498 cells, APOL1 knockdown 786-O cells and APOL1 overexpressing Caki-1 cells. Actin served as an internal control.
    Figure Legend Snippet: APOL1 suppression activates Akt signaling pathway in clear cell renal cell carcinoma. (A) GSEA of RNA-seq data from patient ccRCC tumors compared to their adjacent normal tissues. (B) Gene enrichment analysis of 212 upregulated genes in patient ccRCC tumors. (C, D) Western blot analysis of Akt, NFĸB, GSK3β protein in control and APOL1 knockdown/overexpressing renal cells (C) , and miR-30a transfected A-498 and 786-O cells (D) . (E) Western blot analysis of focal adhesion proteins in control and APOL1 knockdown A-498 cells, APOL1 knockdown 786-O cells and APOL1 overexpressing Caki-1 cells. (F) Western blot analysis of EMT markers in control and APOL1 knockdown A-498 cells, APOL1 knockdown 786-O cells and APOL1 overexpressing Caki-1 cells. Actin served as an internal control.

    Techniques Used: RNA Sequencing, Western Blot, Control, Knockdown, Transfection

    Schematics of APOL1 function in clear cell renal cell carcinoma. APOL1 attenuates renal cancer cell dissemination through FAK/Akt/GSK3β and NFκB-mediated EMT. miR-30a-3p inhibits APOL1 expression.
    Figure Legend Snippet: Schematics of APOL1 function in clear cell renal cell carcinoma. APOL1 attenuates renal cancer cell dissemination through FAK/Akt/GSK3β and NFκB-mediated EMT. miR-30a-3p inhibits APOL1 expression.

    Techniques Used: Expressing



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    apol1 database  (Human Protein Atlas)
    90
    Human Protein Atlas apol1 database
    <t>APOL1</t> is highly expressed in clear cell renal cell carcinoma. (A–C) Heat map of hierarchical clustering (A) , multidimensional scaling (B) and APOL1 mRNA expression (C) in RNA-seq of 9 patient ccRCC tumors compared to their adjacent normal tissues. (D) Kaplan-Meier survival analysis based on the APOL1 expression at stage 4 and grade 4 in the TCGA-KIRC dataset. (E, F) qRT-PCR analysis of APOL1 mRNA (E) and western blot analysis of <t>APOL1</t> <t>protein</t> (F) in A-498, 786-O (primary cancer) and Caki-1 (metastatic) cells compared to HK-2 (normal) cells. Actin served as an internal control.
    Apol1 Database, supplied by Human Protein Atlas, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/apol1 database/product/Human Protein Atlas
    Average 90 stars, based on 1 article reviews
    apol1 database - by Bioz Stars, 2026-03
    90/100 stars
    		  Buy from Supplier

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    APOL1 is highly expressed in clear cell renal cell carcinoma. (A–C) Heat map of hierarchical clustering (A) , multidimensional scaling (B) and APOL1 mRNA expression (C) in RNA-seq of 9 patient ccRCC tumors compared to their adjacent normal tissues. (D) Kaplan-Meier survival analysis based on the APOL1 expression at stage 4 and grade 4 in the TCGA-KIRC dataset. (E, F) qRT-PCR analysis of APOL1 mRNA (E) and western blot analysis of APOL1 protein (F) in A-498, 786-O (primary cancer) and Caki-1 (metastatic) cells compared to HK-2 (normal) cells. Actin served as an internal control.

    Journal: Frontiers in Oncology

    Article Title: Apolipoprotein L1 is a tumor suppressor in clear cell renal cell carcinoma metastasis

    doi: 10.3389/fonc.2024.1371934

    Figure Lengend Snippet: APOL1 is highly expressed in clear cell renal cell carcinoma. (A–C) Heat map of hierarchical clustering (A) , multidimensional scaling (B) and APOL1 mRNA expression (C) in RNA-seq of 9 patient ccRCC tumors compared to their adjacent normal tissues. (D) Kaplan-Meier survival analysis based on the APOL1 expression at stage 4 and grade 4 in the TCGA-KIRC dataset. (E, F) qRT-PCR analysis of APOL1 mRNA (E) and western blot analysis of APOL1 protein (F) in A-498, 786-O (primary cancer) and Caki-1 (metastatic) cells compared to HK-2 (normal) cells. Actin served as an internal control.

    Article Snippet: In the Human Protein Atlas database, APOL1 notably has the highest RNA expression level in many kidney cancer cell lines compared to other cancer types ( ).

    Techniques: Expressing, RNA Sequencing, Quantitative RT-PCR, Western Blot, Control

    miR-30a-3p suppresses APOL1 expression. (A–C) Heat map of hierarchical clustering (A) , multidimensional scaling (B) and miR-30a-3p expression (C) in miRNA-seq of 9 patient ccRCC tumors compared to their adjacent normal tissues. (D) Pearson correlation analysis between miR-30a-3p and APOL1 in patient ccRCC tumors. (E) Kaplan-Meier survival analysis based on the miR-30a expression in the TCGA-KIRC dataset. (F) Western blot analysis of APOL1 protein in control and miR-30a transfected A-498 and 786-O cells. Actin served as an internal control.

    Journal: Frontiers in Oncology

    Article Title: Apolipoprotein L1 is a tumor suppressor in clear cell renal cell carcinoma metastasis

    doi: 10.3389/fonc.2024.1371934

    Figure Lengend Snippet: miR-30a-3p suppresses APOL1 expression. (A–C) Heat map of hierarchical clustering (A) , multidimensional scaling (B) and miR-30a-3p expression (C) in miRNA-seq of 9 patient ccRCC tumors compared to their adjacent normal tissues. (D) Pearson correlation analysis between miR-30a-3p and APOL1 in patient ccRCC tumors. (E) Kaplan-Meier survival analysis based on the miR-30a expression in the TCGA-KIRC dataset. (F) Western blot analysis of APOL1 protein in control and miR-30a transfected A-498 and 786-O cells. Actin served as an internal control.

    Article Snippet: In the Human Protein Atlas database, APOL1 notably has the highest RNA expression level in many kidney cancer cell lines compared to other cancer types ( ).

    Techniques: Expressing, Western Blot, Control, Transfection

    APOL1 overexpression in renal cell carcinoma reduces the metastasis in vitro and in vivo . (A–C) Western blot analysis of APOL1 protein in control and APOL1 knockdown A-498 cells (A) , APOL1 knockdown 786-O cells (B) and APOL1 overexpressing Caki-1 cells (C) . Actin served as an internal control. (D, F, H) Wound healing analysis of control and APOL1 knockdown A-498 cells (D) , APOL1 knockdown 786-O cells (F) and APOL1 overexpressing Caki-1 cells (H) . Scale bar, 100 µM. (E, G, I) Transwell migration and invasion analysis of control and APOL1 knockdown A-498 cells (E) , APOL1 knockdown 786-O cells (G) and APOL1 overexpressing Caki-1 cells (I) cells. Scale bar, 100 µM. (J, K, L) Number of lung metastatic nodules (J) , representative image of the dissected lung (K) and H&E staining of lung (L) in mice intravenously injected with control and APOL1 overexpressing Caki-1 cells. Scale bar, 100 µM.

    Journal: Frontiers in Oncology

    Article Title: Apolipoprotein L1 is a tumor suppressor in clear cell renal cell carcinoma metastasis

    doi: 10.3389/fonc.2024.1371934

    Figure Lengend Snippet: APOL1 overexpression in renal cell carcinoma reduces the metastasis in vitro and in vivo . (A–C) Western blot analysis of APOL1 protein in control and APOL1 knockdown A-498 cells (A) , APOL1 knockdown 786-O cells (B) and APOL1 overexpressing Caki-1 cells (C) . Actin served as an internal control. (D, F, H) Wound healing analysis of control and APOL1 knockdown A-498 cells (D) , APOL1 knockdown 786-O cells (F) and APOL1 overexpressing Caki-1 cells (H) . Scale bar, 100 µM. (E, G, I) Transwell migration and invasion analysis of control and APOL1 knockdown A-498 cells (E) , APOL1 knockdown 786-O cells (G) and APOL1 overexpressing Caki-1 cells (I) cells. Scale bar, 100 µM. (J, K, L) Number of lung metastatic nodules (J) , representative image of the dissected lung (K) and H&E staining of lung (L) in mice intravenously injected with control and APOL1 overexpressing Caki-1 cells. Scale bar, 100 µM.

    Article Snippet: In the Human Protein Atlas database, APOL1 notably has the highest RNA expression level in many kidney cancer cell lines compared to other cancer types ( ).

    Techniques: Over Expression, In Vitro, In Vivo, Western Blot, Control, Knockdown, Migration, Staining, Injection

    APOL1 suppression activates Akt signaling pathway in clear cell renal cell carcinoma. (A) GSEA of RNA-seq data from patient ccRCC tumors compared to their adjacent normal tissues. (B) Gene enrichment analysis of 212 upregulated genes in patient ccRCC tumors. (C, D) Western blot analysis of Akt, NFĸB, GSK3β protein in control and APOL1 knockdown/overexpressing renal cells (C) , and miR-30a transfected A-498 and 786-O cells (D) . (E) Western blot analysis of focal adhesion proteins in control and APOL1 knockdown A-498 cells, APOL1 knockdown 786-O cells and APOL1 overexpressing Caki-1 cells. (F) Western blot analysis of EMT markers in control and APOL1 knockdown A-498 cells, APOL1 knockdown 786-O cells and APOL1 overexpressing Caki-1 cells. Actin served as an internal control.

    Journal: Frontiers in Oncology

    Article Title: Apolipoprotein L1 is a tumor suppressor in clear cell renal cell carcinoma metastasis

    doi: 10.3389/fonc.2024.1371934

    Figure Lengend Snippet: APOL1 suppression activates Akt signaling pathway in clear cell renal cell carcinoma. (A) GSEA of RNA-seq data from patient ccRCC tumors compared to their adjacent normal tissues. (B) Gene enrichment analysis of 212 upregulated genes in patient ccRCC tumors. (C, D) Western blot analysis of Akt, NFĸB, GSK3β protein in control and APOL1 knockdown/overexpressing renal cells (C) , and miR-30a transfected A-498 and 786-O cells (D) . (E) Western blot analysis of focal adhesion proteins in control and APOL1 knockdown A-498 cells, APOL1 knockdown 786-O cells and APOL1 overexpressing Caki-1 cells. (F) Western blot analysis of EMT markers in control and APOL1 knockdown A-498 cells, APOL1 knockdown 786-O cells and APOL1 overexpressing Caki-1 cells. Actin served as an internal control.

    Article Snippet: In the Human Protein Atlas database, APOL1 notably has the highest RNA expression level in many kidney cancer cell lines compared to other cancer types ( ).

    Techniques: RNA Sequencing, Western Blot, Control, Knockdown, Transfection

    Schematics of APOL1 function in clear cell renal cell carcinoma. APOL1 attenuates renal cancer cell dissemination through FAK/Akt/GSK3β and NFκB-mediated EMT. miR-30a-3p inhibits APOL1 expression.

    Journal: Frontiers in Oncology

    Article Title: Apolipoprotein L1 is a tumor suppressor in clear cell renal cell carcinoma metastasis

    doi: 10.3389/fonc.2024.1371934

    Figure Lengend Snippet: Schematics of APOL1 function in clear cell renal cell carcinoma. APOL1 attenuates renal cancer cell dissemination through FAK/Akt/GSK3β and NFκB-mediated EMT. miR-30a-3p inhibits APOL1 expression.

    Article Snippet: In the Human Protein Atlas database, APOL1 notably has the highest RNA expression level in many kidney cancer cell lines compared to other cancer types ( ).

    Techniques: Expressing